Two researchers examined the question of why children seemed to be so less affected than adults when infected with COVID-19. Before they could begin their study, they had to study the statistics to determine first of all if this were even true. The statistics backed up the assumption far more than they imagined it would. In the end, they determined that, as of now, no one fully understands why COVID-19 has such little affect on children and why it spikes in severity of effect on adults from 60, where the spike starts, to 70, where it more gradually increases with age once again.
In summary, the observation that, compared with other respiratory viruses, children have less severe symptoms when infected by SARS-CoV-2 is surprising and not yet understood. Furthermore, it is also uncertain why children with the usual risk factors for infections, such as immunosuppression, are not at high risk for severe COVID-19, while previously healthy children can on rare occasions become severely ill.110–113 222 Although there are several hypotheses for why children are less affected by COVID-19, with the notable exception of age-related changes in immune and endothelial/clotting function, most do not explain the observed age-gradient in COVID-19 with severity and mortality rising steeply after the age of 60 to 70 years. Unravelling the mechanisms underlying the age-related differences in the severity of COVID-19 will provide important insights and opportunities for the prevention and treatment of this novel infection.